Objective: microRNAs (miRNAs) have important potential as biomarkers in the diagnosis and prognosis of ischemia/reperfusion (I/R) injury in coronary artery bypass grafting surgery (CABG). This study investigated the relationship between preoperative (preop) and postoperative (post-op) cardiac parameters and miRNA expressions in CABG. -/- Methods: We analyzed a total of 94 individuals (CABG, n= 46 and healthy control, n=48). Quantitative real-time polymerase chain reaction (qRT) was performed to determine plasma miRNA expressions (miR-21, miR-181a, miR-199a, miR-199b, and miR-320a-5p) in triplicates: before surgery, (...) 1 hour after surgery, and 24 hours after surgery. The target genes and pathways of miRNA were determined using bioinformatic analysis. The biomarker potentials of miRNAs were evaluated with receiver operating characteristic (ROC) curve analysis. -/- Results: All miRNAs were significantly downregulated (p < 0.05). Troponin I, LVEF, CPK, and CK-MB were found to be statistically significant for operation groups (p < 0.05). miRNA expressions and cardiac markers were associated with troponin I and/or CK-MB. In ROC analyses, miR-199a was a good diagnostic marker. CREBRF and ZNF704 genes may be a target for these miRNAs. -/- Conclusions: Downregulation of miR-199a has a regulatory role in ischemia/reperfusion. They may contribute to CABG pathology through these two genes involved in signaling cascades to turn on protein response and ion binding. (shrink)

NUTRIÇÃO SOBRE A AZOOSPERMIA EM BOVINOS -/- -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- AZOOSPERMIA EM BOVINOS -/- INTRODUÇÃO -/- A falta completa de esperma no ejaculado pode ser devido a uma falha no processo de espermatogênese ou relacionada a causas no transporte do esperma. Com relação ao transporte, o esperma pode ser impedido de ser ejaculado mediante bloqueios ou oclusões no sistema do ducto extragonadal, ou (...) por causa de uma disfunção ejaculatória. Nos cães, por exemplo, a possibilidade de oclusão ser a causa pode ser determinada por medições de fosfatase alcalina (ALP) no plasma seminal, já que a ALP se origina do epidídimo e seminífero epitélio tubular. Se a concentração de ALP no fluido seminal for superior a 5000 UI/l, a amostra ejaculada contém fluido desses tecidos e a oclusão pode ser descartada. -/- As causas testiculares da azoospermia incluem a falha da espermatogênese, que pode ser causada por uma série de fatores; estes incluem fatores hormonais, imunológicos, congênitos, tóxicos, patogênicos, traumáticos e nutricionais. Aqui, as supressões na região do AZF (que contém sub-regiões AZFa, AZFb e AZFc) no cromossoma Y desempenham um papel importante, representando 10-15% dos casos de azoo- e oligospermia. Na região AFZc, o gene DAZ, que é suprimido na azoospermia, é considerado importante no controle espermatogênico, uma vez que a sua eliminação é frequentemente detectada em homens e/ou animais inférteis. -/- A perda total da capacidade de formação de espermatozoides pelo epitélio testicular e, portanto, a ausência de espermatozoides viáveis ou não no volume ejaculado pelo animal é denominado como azoospermia (VARNER et al., 2000), um macho nessas condições deve ser imediatamente retirado dos processos produtivos e não é, de forma alguma, viável para fins reprodutivos. A origem da causa pode ter caráter nutricional, ou outras, sendo multifatoriais; em processos crônicos severos pode-se chegar à azoospermia reversível, que é diagnosticada e corrigida de forma oportuna. Entre os principais fatores de caráter nutricional temos: -/- 18.1 Nitratos (NO3-) e nitritos (NO2-) -/- Quando os ruminantes consomem uma alimentação com elevadas concentrações de nitratos (presente principalmente nas forrageiras) parte do nitrato não pode ser imediatamente convertido em nitrito e, por fim, em amoníaco (todas essas transformações acontecem no rúmen mediante a flora microbiana); isso faz com que nitrato e nitrito se acumulem no rúmen. A adição do nitrato no rúmen intensifica o problema. O envenenamento por nitrato ocorre quando o nível de nitrito presente no rúmen excede a capacidade do microbiota para convertê-lo em amoníaco. Quando isto acontece, o nitrato e o nitrito são absorvidos através da parede do rúmen e entram na circulação sanguínea. É o nitrito que causa a toxicidade. -/- Estudou-se o equilíbrio ácido-básico e sua relação com a reprodução e produção, postulando a hipótese de que esse equilíbrio afeta os mecanismos endócrinos e metabólicos, além dos reprodutivos. -/- 18.2 Relação energia:proteína -/- Quando a alimentação apresenta deficiências de energia aumenta-se a degradação das gorduras (provenientes do tecido adiposo), acompanhada pela redução da liberação de insulina (hipoinsulinemia) afetando-se a lipogênese, mobilizando-se mais gordura corporal do que se sintetiza. -/- Situações como a acidose ruminal (excesso de grão e deficiência em fibras) ou alcalose ruminal (excesso de ureia com baixa energia digerível) resultam em perturbações sobre a fertilidade; além disso, deficiências energéticas graves que levam à cetose causam estresse com a liberação de catecolaminas, ACTH e TSH que afetam a secreção de GnRH, afetando por fim, a espermiogênese. -/- -/- Uma diminuição de energia na alimentação gera hipoglicemia que, ao mesmo tempo, produz hipoinsulinemia incrementando assim a lipólise em tecidos, gerando como produtos as cetonas. -/- A hipoinsulinemia juntamente com a cetonemia e a geração de beta-endorfinas, por problemas na alimentação, reduzem notavelmente a síntese de GnRH. A GnRH reduz a liberação do LH e FSH. A diminuição da liberação do LH provoca azoospermia hipogonadotrópica com efeitos de estimulação hormonal anormais segundo a avaliação endócrina, bem como a obstrução testicular inexplicada. -/- Se houver um aumento significativo na liberação de FSH, a azoospermia hipogonadotrópica é refletida em diagnóstico como disfunção testicular. -/- 18.3 Minerais (Selênio Se) -/- Quando os níveis de Se na dieta são deficientes, ocorrem falhas na formação e maturação espermática. O Se mostra uma grande influência na fertilidade do macho afetando a qualidade do sêmen, o plasma seminal contém elevadas quantidades de GSH-Px, cuja função é proteger a membrana do espermatozoide do ataque peroxidativo; além disso, na cauda do gameta masculino há um selenopeptídeo que faz com que, em uma deficiência de Se, produza-se uma fratura no meio da cauda do espermatozoide. -/- O esperma dos animais com deficiência de Se apresentam pobre motilidade com características de desenvolvimento anormal na cauda do esperma. Demonstrou-se que a deficiência de Se, não somente precipita o problema em reprodutores, mas que o esperma deformado, foi menos efetivo na subsequente fertilização do ovócito ovulado (HAWKES et al., 2001), ou seja, animais que possuem deficiência desse mineral podem ter esperma inapropriado para a destinação de inseminação artificial ou mesmo a monta natural, uma vez que a taxa de concepção estará bastante baixa. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. -/- BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. -/- BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. -/- CHENOWETH, Peter J.; LORTON, Steven (Ed.). Animal Andrology: Theories and Applications. Boston: Cabi, 2014. -/- -/- DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. -/- DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. -/- DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. -/- FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. -/- FRENEAU, G. E.; GUIMARÃES, J. D. Curso Teórico-Prático de Andrologia Bovina. Goiânia: Laboratório de andrologia e Tecnologia de Sêmen da Escola de Veterinária da Universidade Federal de Goiás, 2000. -/- GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. -/- HAWKES, WAYNE CHRIS; TUREK, PAUL J. Effects of dietary selenium on sperm motility in healthy men. Journal of Andrology, v. 22, n. 5, p. 764-772, 2001. -/- MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. -/- SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. -/- THATCHER, W. W. et al. Strategies for improving fertility in the modern dairy cow. Theriogenology, v. 65, n. 1, p. 30-44, 2006. -/- TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. -/- VARNER, D. D. et al. Techniques for evaluating selected reproductive disorders of stallions. Animal reproduction science, v. 60, p. 493-509, 2000. (shrink)

Darwinism presents a paradox. It discredits the notion that one’s life has any intrinsic meaning, yet it predicts that we are designed by Darwinian natural selection to generally insist that it must—and so necessarily designed to misunderstand and doubt Darwinism. The implications of this paradox are explored here, including the question of where then does the Darwinist find meaning in life? The main source, it is proposed, is from cognitive domains for meaning inherited from sentient ancestors—domains that reveal our evolved (...) human nature as the fool that it is: given to distractions and delusions of many kinds, designed by natural selection primarily for one essential purpose—to allay our instinctual fear of failed legacy, rooted in our uniquely human awareness that we are not immortal. Darwinism, however, also teaches that genuine legacy is a fate enjoyed only by individual genes. Accordingly, as argued here, those genes with the grandest legacy—and hence rampant within us—are of two types: “legacy-drive” genes delude us into thinking that the legacy can be individually and personally ours; and “leisure-drive” genes distract us from the agonizing truth that it can never be. The most rudimental delusion of legacy is the perception of offspring as vehicles for memetic legacy—the transmission of resident memes from one’s mind to the minds and behaviors of offspring— thus also ensuring genetic legacy: the transmission of resident genes, including importantly, genes inherited from ancestors that influence both legacy and leisure drives. Today, legacyand leisure-drive genes reveal their phenotypes across a wide range of human affairs, and together with the phenotypes of survival- and sex-drive genes, they provide a foundation for a novel view of the Darwinian roots of cultural evolution. (shrink)

Darwinism presents a paradox. It discredits the notion that one’s life has any intrinsic meaning, yet it predicts that we are designed by Darwinian natural selection to generally insist that it must—and so necessarily designed to misunderstand and doubt Darwinism. The implications of this paradox are explored here, including the question of where then does the Darwinist find meaning in life? The main source, it is proposed, is from cognitive domains for meaning inherited from sentient ancestors—domains that reveal our evolved (...) human nature as the fool that it is: given to distractions and delusions of many kinds, designed by natural selection primarily for one essential purpose—to allay our instinctual fear of failed legacy, rooted in our uniquely human awareness that we are not immortal. Darwinism, however, also teaches that genuine legacy is a fate enjoyed only by individual genes. Accordingly, as argued here, those genes with the grandest legacy—and hence rampant within us—are of two types: “legacy-drive” genes delude us into thinking that the legacy can be individually and personally ours; and “leisure-drive” genes distract us from the agonizing truth that it can never be. The most rudimental delusion of legacy is the perception of offspring as vehicles for memetic legacy—the transmission of resident memes from one’s mind to the minds and behaviors of offspring—thus also ensuring genetic legacy: the transmission of resident genes, including importantly, genes inherited from ancestors that influence both legacy and leisure drives. Today, legacy- and leisure-drive genes reveal their phenotypes across a wide range of human affairs, and together with the phenotypes of survival- and sex-drive genes, they provide a foundation for a novel view of the Darwinian roots of cultural evolution. (shrink)

Recent prescriptions for rescuing civilization from collapse involve extending our human capacity for empathy to a global scale. This is a worthy goal, but several indications leave grounds for cautious optimism at best. Evolutionary biology interprets non-kin helping behaviors as products of natural selection that rewarded only the transmission success of resident genes within ancestors, not their prospects for building a sustainable civilization for descendants. These descendants however are now us, threatened with ruin on a warming, overcrowded planet—and our evolutionary (...) bequeathal, in giving us empathy, may have also given us potential for resolve in guiding cultural evolution for the best interests of humanity. But can the latter trump the best interests of our genes? And if so, now that the liberal copying success of our genes is in conflict with the best interests of a sustainable civilization for our descendants, do the latter risk losing the empathic instinct presently called upon to save them? (shrink)

Since the disintegration of the USSR Eurasia has gained a new geopolitical and strategic significance. Fifteen Countries emerged as a result of disintegration, among which only the Russian Federation was the successor state. The post-soviet era especially the era of the 1990s was a political and economic trauma for the Russian Federation and the post-soviet space. But Eurasianists were well aware of the American unilateralism and American ‘Grand Chessboard strategy” that was solely aimed at encircling Russian geography. With these concerns, (...) the Eurasianists advised the Russian political and military elites to initiate the Eurasian Union Project. This paper briefly sketches the Russian historical Eurasian dream, which deeply rooted in Russian imperial history, and discusses the importance of Eurasian philosophy for the political and economic stability of Russia-Eurasia. The paper also illustrates the challenges and opportunities for Eurasian integration and for the establishment of multipolar world order. Moreover, the paper also briefly outlines the geopolitical rationale behind the Eurasian project as a key objective of contemporary Russian foreign policy and geopolitics. (shrink)

Abstract: In a former paper [21], an exact image compression based on bit-planes blocking was proposed. The proposed algorithm uses two bit codes for block representation. The outcome of the encoding process is two streams: Main Bit Stream, MBS and Residual Bit Stream, RBS. The algorithm core is searching for the greatest block of Unicode to encode in main stream and if not found until size of two by two then it will be kept as is in residual stream. In (...) this paper, a lossy version of that algorithm is presented. The change in the base algorithm is in the definition of the unary-code-block is eased to be above certain percent. The percent is varied from plane to another as their contribution to image power varies. The testing of the proposed algorithm shows comparable results. Image degradations seems restorable even for high compression ratios. (shrink)

This study investigated adolescent students’ nutritional knowledge in boarding schools and potential strategies for improving their nutritional status in the Ido-Osi Local Government Area of Ekiti State, Nigeria. The researcher used purposive sampling to select three government colleges and private college boarding schools in the Ido-Osi Local Government area. The sample consisted of 80 boarding house students. Data was collected using a questionnaire, and the statistical analysis involved frequency and percentages. The findings revealed that a good percentage of the boarding (...) school students have good nutritional knowledge. The majority of students believed that both the Federal and State Government, as well as schools, parents, and communities, should work together to improve the food system in order to combat nutritional challenges in boarding schools. Thus, the study recommends that the Government, parents, schools, and communities collaborate to address any nutrition issues among adolescent students in boarding schools. This could involve initiatives such as establishing school gardens and providing support to local farmers, among other strategies. Future research should aim to enhance our understanding of adolescent students' nutritional knowledge in boarding schools and develop effective strategies to improve their nutritional status. This will contribute to the overall health and well-being of these students during their critical developmental years. (shrink)

The police are one of the important law enforcement agency in Bangladesh. Police are the best agency to protect human rights. Indeed, the police have a special responsibility to protect people. In addition, to their duty, they also serve in people's social and moral call, especially during COVID-19 situations they imprint many examples of humanity. People experience many good deeds of police during a national disaster as well. However, allegation against the police for violations of human rights is not uncommon. (...) Cases of torture, death in police custody, involvement in the drug trade and robberies, entrapment with drug, helping in land grabbing, etc. are being published in newspapers. Nevertheless, to protect human rights or to take care of human rights is the prime function of the police. This research efforts to find out the answer to why police violate human rights. This research may help police professionals or administrators in taking policy initiatives to erase the negative image of the police. (shrink)

Social media has become a phenomenon that is changing all spheres of life tremendously. It is affecting the peaceful coexistence of people in the society both positively and negatively. Almost every government throughout the world is reacting in one way or the other to this influence, especially the perceived adverse influence of social media on the peaceful coexistence of people in the society. This paper aims at exploring the interplay between the Federal Government of Nigeria and social media in relation (...) to the peaceful coexistence of people in the country. Public Sphere Theory is used as the theoretical framework. The paper is a follow-up to a study on how Baptist pastors in the Ibadan metropolis are using social media in conflict resolution and promotion of peaceful coexistence among members of their church. It further reviews some existing literatures on the subject matter where the history of social media in Nigeria and some specific effects of social media in relation to peaceful coexistence in Nigeria are explored before exploring the interplay. Some recommendations are given to the Federal Government of Nigeria at the end of the paper. The paper concludes by warning the Federal Government of Nigerian and other governments throughout the world in regulating the use of social media so that the original purpose of the regulation will not be defeated. (shrink)

Islam' literally means submission but when the term is used in a religious context it means submission to Allah alone. Accordingly, a Muslim is one who submits to the Divine injunctions and does not deviate from them. "Al-Islam implies that you testify that there is no god but Allah and that Muhammad is the Messenger of Allah and you establish prayer, pay zakat, observe the fast of Ramadan, and perform pilgrimage to Holy Ka'ba at Mecca once in a lifetime if (...) you are solvent enough (to bear the expense of) journey". The most important principle in Islam is worshiping one and only one God. Islam calls for human rights; no one is better than another with his colour, race, gender, or culture. All are equal and difference among people is based on piety and doing good deeds. Islam considers all human free and has free will. Islam calls protecting environment. Islam calls all people to recognize that our life in the planet is short and that we should prepare ourselves for the second eternal life where everyone will be judged by the Creator in what he did in his first life for himself, community, and environment. In brief, the teachings of Islam are based on Quran (Holy book of God revelation to prophet Mohamed) and Prophet Mohamed (peace upon him) sayings and practices. The teachings are based on two wings: Worship: This is to follow the five pillars of Islam and believe in the 6 pillars of faith. Good deeds: This to do what is beneficial to community and to mankind. The fulfilment of these duties means the fulfilment of the remaining duties as well. That is why it is mentioned in a tradition that only these duties have been called "Islam". Language: Arabic. (shrink)

Nigeria is constitutionally a secular state but underneath, religion plays a fundamental role in the socio-political governance of the people. The integration of religion and politics in Nigerian political history by her founding fathers is believed to be one major problem behind the current religious violence and political instability bedevilling the country today. The aim of this paper is to understand why the political history of Nigeria is shrouded in religious bigotry by providing the historical overview of the background that (...) has influenced the socio-religious and political activism in Nigeria. The paper also examined the passivism or activism of the two major religions: Christianity and Islam in seeking socio-political justice and control in the political activities of Nigeria and the aftermath of this power play in the affairs of governance. Lastly, the paper critiqued the effect of religious involvement in either promoting or reducing socio-religious and political crisis in contemporary Nigerian society. The paper adopted the historical and descriptive research methods and argues that the present religious violence and political instability, is predicated by the “divide and rule” and the pretentious “amalgamation” policy of the Colonial Administrators that favoured the North against the South. The seed planted by the Colonial Administrators before Independence is what has gradually grown into a monster that is threatening the peaceful co-existence of the Nigerian State. The paper concludes that to restore peaceful co-existence in a heterogeneous State like Nigeria, there is need for a realistic constitutional amendment that will truly reflect the heterogeneous secular nature of Nigeria and consider the wishes of the Federating units and by addressing the political, religious and other social-economic issues that are threatening the peaceful co-existence of Nigeria society and guarantee every religious group equality before the law. (shrink)

This is a study about emergence and development of the notion of ‘al-Adab al-Islami’ or Islamic Literature. The focus is on the conceptual thinking underlying Islamic Literature as a discourse. The term "Islamic Literature" consists of two fundamental components, "Islamic" and "Literature". In order to understand the concept of Islamic Literature, an appropriate understanding of the nature within Islam is inevitable. This study looks at the fundamental question whether Islamic Literature should give priority to its religious or its literary proper (...) ties. This study observes the development of the concept of an Islamic Literature throughout the history. Islamic Literature draws its inspiration from the Quran and the Hadith, the sayings of the Prophet Muhammad. (shrink)

Responsive governance during the COVID-19 pandemic became a severe challenge for countries worldwide. With a relatively poor healthcare structure, Bangladesh performed moderately well in managing the first wave of the pandemic (March-December 2020). With substantive policy and decision-making support from the Centre, local governments collaborated with various relevant actors to enhance their pandemic-related services. In this background, this research used an integrative framework to study a case of local-level collaborative governance-the Saturia Model. Based on the authors' experience, reflections and review, (...) this analysis explores various socioeconomic and environmental factors behind the effectiveness of this collaboration in containment policies and providing support services to vulnerable groups. Findings indicate that coordination between state and non-state actors, resource mobilization, access and communication, community engagement and the adaptative capacity of the government are vital for making such collaborations work in a crisis. The lessons are valuable for prospective understanding and policy interventions. (shrink)

This chapter examines whether high prices for gene therapies are justified and whether the problems associated with high prices can be solved by the "pay for performance" (P4P) reimbursement model. To this end, we first describe how prices for new drugs, including gene therapies, are set in Germany (section 2.). P4P is then presented as an example of a reimbursement model (section 3.). The subsequent ethical analysis (section 4.) first examines whether P4P models can sustainably guarantee the right (...) to health and healthcare for all people (section 4.1; cf. on the "sustainable right to health" already Alex, 2021). It is then shown that cost-benefit analyses for setting prices for new gene therapies must be viewed critically from an ethical perspective and pose a problem for equity of access and thus also for the sustainable guarantee of a right to health (section 4.2). The final question is whether P4P is compatible with the idea of human dignity (Article 1 I 1 of the German Basic Law) (section 4.3; cf. already König et al., 2020). -/- Alex, K. (2021): Ethical conceptualization of a sustainable right to health(care). In: Schildmann, J. et al. (eds.): Defining the value of medical interventions. Normative and empirical challenges. Kohlhammer, Stuttgart: 29-48. PMID: 36256802 König, J. et al. (2020): Am individuellen Therapieergebnis orientierte Erstattungsverfahren in der Onkologie: ethische Implikationen am Beispiel der CAR-T-Zelltherapie. In: Ethik Med 32: 85–92. doi: 10.1007/s00481-020-00565-3. (shrink)

Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the (...) editing and design metaphors suggest. Such metaphors are therefore highly problematic phrases in the context of new gene technologies, for two reasons. On one hand, to design a child of choice by modifying the genome would require modifying any gene of choice, which is more than can be done with current gene technologies, such as CRISPR/Cas. On the other hand, a modification of genes would need to be enough to create any characteristic of choice in the future child. The latter presupposes the assumption of genetic determinism. Moreover, the CRISPR/Cas technology can not only be used in a potentially therapeutic manner at the germline level. In addition, there is the (more likely) scenario of a future clinical therapeutic use of these new gene technologies for modifying the DNA sequence of other cells of the body (somatic genome editing). There is also the option of modifying the epigenome, that is, the spatial configuration of DNA (epigenome editing) (see table 1). Like genetics and genome editing, epigenetics has been at the center of recent popular scientific and ethical discourse as well as scientific debates. The concept of epigenetics has given rise to very different notions of inheritability and responsibility for health, which, however, are oftentimes based on scientifically controversial basic assumptions. That there continues to be covert genetic determinism in the form of epigenetic determinism (see table 2) in debates about epigenetics has been pointed out in ethical analyses of epigenetics. Neither genetic determinism nor epigenetic determinism has been confirmed scientifically. It is therefore important to recognize the concepts that are discussed (and sometimes harshly criticized) in debates about genome editing and epigenetics—for example, concepts about the causal role of DNA for our own life course. This importance is based on the fact that if we understand such controversial concepts, we will be able to remain critical when evaluating scientific knowledge and ethical arguments about genome editing and epigenetics. This chapter, therefore, explains some of these concepts. For an ethical analysis of epigenetics as well as of genome editing, it is necessary to understand and critically reflect upon the underlying concepts of genetic determinism and other, related -isms. The following section offers a detailed introduction to these -isms (section 2; see also table 2). Section 3 provides an ethical analysis of genome editing and epigenetics based on the explanations in section 2. Section 3 focuses on inheritability and responsibility, justice, safety, the problem of consent, and the effects of genome editing and epigenetics on embryos and future generations. This section does not discuss in detail further points that can be found in ethical debates about epigenetics as well as in ethical debates about genome editing. These points include (among others): • fear that the findings of epigenetics and that the methods of genome editing are misused—this also with respect to eugenics and enhancement; • naturalness—an issue we mention in passing a few times in the following analysis; • a possible connection between the genome/epigenome and the concept of human dignity, and the derived danger of instrumentalization and infringement of autonomy when intervening in the genome or epigenome. Since current discourse about ethical issues associated with genome editing focuses mainly on germline interventions, which are, for instance, interventions into a human embryo’s genome, we mainly focus on germline interventions when comparing the debates on genome editing and on epigenetics in section 3. (shrink)

The Philosopher Queen: Feminist Essays on War, Love, and Knowledge. By Chris Cuomo. Lanham, Md.: Rowman and Littlefield Publishers, Inc., 2003. The Philosopher Queen is a powerful illustration of what Cherríe Moraga calls a "theory in the flesh." That is, theorizing from a place where "physical realities of our lives—our skin color, the land or concrete we grow up on, our sexual longings—all fuse to create a politic [and, I would add, an ethics, spirituality, and epistemology] born out of necessity" (...) (Moraga 21). Cuomo's theory in the flesh combines standard philosophical essays with personal narratives and invites us to do philosophy from this joyful and witty place. Readers are invited to reframe and reexamine war, science, gender, sexuality, race, ecology, knowledge, and politics in a voice that is fearless, funny, faithful, and feminist—one that disrupts common understandings of how philosophy ought to be done. Instead philosophy should help us to "negotiate a wild, wicked world, and to provide some understanding of being and existence. The best philosophy aims to promote good and to produce knowledge, and therefore enable flourishing" (xi). Accepted philosophical approaches alone are inadequate. Life's challenges resist formulaic solutions. Knowledge is not always produced through neat deductions: truths are partial, power divides, stomachs growl, hearts are broken, and emotions influence... (shrink)

Is capitalism inherently predatory? Must there be winners and losers? Is public interest outdated and free-riding rational? Is consumer choice the same as self-determination? Must bargainers abandon the no-harm principle? Prisoners of Reason recalls that classical liberal capitalism exalted the no-harm principle. Although imperfect and exclusionary, modern liberalism recognized individual human dignity alongside individuals' responsibility to respect others. Neoliberalism, by contrast, views life as ceaseless struggle. Agents vie for scarce resources in antagonistic competition in which every individual seeks dominance. This (...) political theory is codified in non-cooperative game theory; the neoliberal citizen and consumer is the strategic rational actor. Rational choice justifies ends irrespective of means. Money becomes the medium of all value. Solidarity and good will are invalidated. Relationships are conducted on a quid pro quo basis. However, agents can freely opt out of this cynical race to the bottom by embracing a more expansive range of coherent action. (shrink)

This chapter uncovers the complex negotiations for authority in various representations about futures of life which have been advanced by different branches of the sciences, and have culminated in the emerging concept of life as algorithm. It charts the historical shifts in expertise and representations of life, from naturalists, to mathematical modellers, and specialists in computation, and argues that physicists, game theorists, and economists now take a leading role in explaining and projecting futures of life. The chapter identifies Richard Dawkins (...) and Max Tegmark at the forefront of the concept of life as algorithm: the first inspired by game theory as a means to study evolution; the second proposing that a materialist basis of life could place humans and artificial intelligence on an equal footing. Through close reading of their respective texts, the chapter demonstrates that both thinkers consider life as an algorithm programmed to achieve success in survival and reproduction. (shrink)

It is argued that the analysis by which the gene are differentiated in the dialogue is an exercise in studied ambiguities informed by an Eleatic logic of strict dichotomy that was the underpinning of the Sophist's method of division. By this dialectical drill, Plato shows that the metaphysics underlying the Visitor's method fails to adequately distinguish what it means to have a character from what it means to be a character, and therefore remains inadequate to track down the sophist (...) or to distinguish him from the philosopher: Eleaticism, as critically examined by Plato, proves to be means to disguise, not to discover the sophist. (shrink)

The Global Media and Information Literacy Week commemorates the progress in achieving “MIL for all” by aggregating various MIL-related local and international events and actions across different disciplines around the world.The MIL Global Week 2018, 24 to 31 October, was marked by the United Nations Educational, Scientific and Cultural Organization in collaboration with various organizations including the UN Alliance of Civilizations, the Global Alliance for Partnership on MIL, the International Federation of Library Associations, the International Association of School Libraries, and (...) the UNESCO-UNAOC University Cooperation Programme on Media and Information Literacy and Intercultural Dialogue. (shrink)

The motto of this research article is to present how Bangladeshi University students use the mixture of both English and Bengali language as their spoken language. It can be said undoubtedly that English is the vast spoken language in the whole world as well as spreading to a large extent. Bangladesh is not different from other countries as well as English has been taught every level an every medium of education here and in recent times it is seen that English (...) is used by the university students when they talk with each other I mean we can see a mixture of two languages. Each language has a social function which no other language could possibly fulfill (Hudson, 1996). Perhaps that is why code switching has become a common phenomenon in our everyday conversations in the recent years in Bangladesh. Young people randomly style switch in their daily interactions. This research paper also explores the possible propelling factors as well as stereotypical patterns behind this scenario. The data collected for the study reveals different factors as the causes behind this practice of code-switching and its impact on language behavior. (shrink)

European colonialism is an extremely controversial affair in world history that is also discussed today. This paper explores the influence of these happenings as the world incorporates the culture of European in every step of life. Europe dominated almost the entire world and its people were leaders in science and technology. European languages, literature, and culture spread all over the globe. Decisions in Europe largely determined global events for centuries. The other continents did not approach European power until after WW1 (...) or WW2. Europe consisted of constantly competing nations, and this competition spurred development. Europe achieved world hegemony in the years after 1500 A.D., primarily due to technological advancements, scientific research, political development of nations with stable succession and continuity, and a culture dominated by Christianity. These advantages were translated into military power, projected all over the world. (shrink)

The study has been presented the role of home environment to learn English language particularly in Bangladesh. Parental as well as siblings role is very essential to grow the sense of learning and the learners can grow a great influence by it. Parents’ as well as siblings’ positive attitude, education and awareness according to individual requirements and needs are provided constant encouragement and support for the learners. Parents make the greatest difference to achievement through supporting their learning at home rather (...) than supporting activities in school. A learner, whose family members are habituated to use English at home, feels encouraged to learn English which facilitates learning process. My findings, on the other hand, show that children of those parents who are ignorant of providing sound family atmosphere, lack confidence as well as self-esteem. This study also inspects the impact of home environment on children’s achievement in English language. The findings reveal that there is a constant relationship between the role of family and students’ academic achievement. (shrink)

Socio-Economic Impacts of Co-operative Societies: An Empirical Study -/- Author / Authors :Md. Ruhul Amin and Mohammed Mahin Uddin Page no.179-193 Discipline : Applied Economics/ Management/ Commerce Script/language : English/Roman Category : Research paper Keywords: Co-operative, Development, Society, Constrains, Constitution, Comilla.

The use of technology has become an important part of the learning process in and out of the class. Technology continues to grow in importance as a tool to help teachers facilitate language learning for their learners. This study focuses on the role of using new technologies in learning English as a second/foreign language. It discussed different attitudes which support English language learners to increase their learning skills through using technologies. In this paper, the researcher defined the term technology and (...) technology integration, explained the use of technology in language classroom, reviewed previous studies on using technologies in improving language learning skills, and stated certain recommendations for the better use of these technologies, which assist learners in improving their learning skills. The literature review indicated that the effective use of new technologies improves learners’ language learning skills. (shrink)

It has a long history of teaching English literature and language in this sub-continent. The European colonial rulers introduced this teaching with the motive of serving their own purpose, but paradoxically this teaching has benefited the people of this soil as well in many ways. From the very beginning, the English department of any college or university has been treated as one of the most prestigious departments that have produced the best citizens of this soil. But recently the teaching scenario (...) of these departments in Bangladesh is being severely affected owing to different kinds of changes that have occurred in the social and academic arenas of the country. It is now the demand of the present time that the English departments of the universities of our country should take proper steps to address those problems properly and bring back its reputation. The present study attempts to find out the problems that are affecting the teaching and learning process of these departments and thereby damaging the glory and reputation of them, and also to provide some suggestions to cope with those problems. (shrink)

A Troublesome Inheritance, by Nicholas Wade, should be read by anyone interested in race and recent human evolution. Wade deserves credit for challenging the popular dog­ma that biological differences between groups either don't exist or cannot ex­plain the relative success of different groups at different tasks. Wade's work should be read alongside another re­cent book, The 10,000 Year Explosion: How Civilization Accelerated Human Evolution, by Gregory Cochran and Henry Harpending. Together, these books represent a ma­jor turning point in the public (...) debate about the speed with which relatively isolated groups can evolve: both books suggest that small genetic differences between members of different groups can have large impacts on their abilities and propensities, which in turn affect the outcomes of the societies in which they live. (shrink)

The Aristotelian axiom that function follows form was beautifully instantiated in molecular biology by the discovery of DNA’s structure that immediately suggested how DNA might work as depository and vehicle for genetic information. However, later on molecular biology became infatuated with the gene that became the center of the universe. This gene-centered viewpoint is an obstacle for the emerging field of evo-devo aiming at finding the causal connections between evolution and biological development. Here it is argued that molecular (...) biology must reject the narrow-minded causality associated with the gene-centered view and so it must recover to the spirit of Aristotelian natural history and its four types of causation in order to foster the evo-devo field of research. (shrink)

One notable component to look at in the teaching-learning process is the way the subject is taught because one way or another, students are greatly affected by it. Viewing students’ perspectives on the use of the different teaching methods, this study determined the frequency of use of these teaching methods and their level of satisfaction. Through a systematic investigation, the findings from a critical questionnaire administered to first-year BS Hospitality Management college students at Ifugao State University were analyzed and summarized. (...) The frequency of use of the indicated instructional strategies was shown to have a significant relationship with student satisfaction in this study. Furthermore, the data reveal a substantial difference in student satisfaction with instructional approaches utilized before and during the pandemic. Students, on the other hand, prefer the teaching techniques employed before the outbreak to those utilized during the pandemic. (shrink)

Since Aristotle the central question in biology was the origin of organic form; a question put in the backyard by neo-Darwinism that considers organic form as a side effect of the interactions between genes and their products. On the other hand, the fashionable notion of self-organization also fails to provide a true causal explanation for organic form. For Aristotle form is both a cause and the principle of intelligibility and this coupled to the classical concepts of potentiality and actuality provides (...) a rational framework,currently embodied in the contemporary concept of ‘attractor’, for understanding the origin of organic form. (shrink)

For some the gene-centered reductionism that permeates contemporary neo-Darwinism is an obstacle for finding a common explanatory framework for both biological and cultural evolution. Thus social scientists are tempted to find new concepts that might bridge the divide between biology and sociology. Yet since Aristotle we know that the level of explanation must be commensurate with the particular question to be answered. In modern natural science there are many instances where a reductionist approach has failed to provide the right (...) answer to the corresponding question. Thus social scientists risk becoming non-relevant when mimicking some features of the natural sciences (such as hard or soft reductionism) just for the sake of it, instead of finding autonomous explanations commensurate with the level of phenomena studied by social science. (shrink)

Molecular biology is a relatively new and very successful branch of science but currently it faces challenges posed by very complex issues that cannot be addressed by a traditional reductionist approach. However, despite its origins in the providential shift of some theoretical physicists to biology, currently molecular biology is immersed in a blind trend in which high-throughput technology, able to generate trillions of data, is becoming the leading edge of a discipline that has traded rational and critical thinking for computer (...) power, data crunching and statistics in hope of finding, once more, its way. However, the complex questions facing MB may only be solved by a paradigm shift in the causal way of thinking, so that complex, emergent, non-linear phenomena may be effectively understood in top-down and not in bottom-up terms. (shrink)

The purpose of this paper is to present a critique of the current view that reduces cancer to a cellular problem caused by specific gene mutations and to propose, instead, that such a problem might become more intelligible, if it is understood as a phenomenon that results from the breakdown of the morphological plan or Gestalt of the organism. Such and organism, in Aristotelian terms, is characterized for presenting a specific morphe or logos (form) and for having a telos (...) (end) to fulfill. A malignant tumor represents an entity separated from both the organic logos and the organic telos. According to the basic postulates of Semiophysics – a blend of Aristotelian physics and Catastrophe Theory developed by René Thom – an organism is a source (original) form individuated by a dominant pregnance that corresponds to its morphogenetic field. Here it is suggested that cancer in aged individuals might result from the progressive exhaustion of developmental constraints that regulate the process of ontogeny, that it is expected to go from the fertilized non-differentiated zygote to the mature fully developed organism, because there is no further point ahead in the developmental pathway past the reproductive age. Cancer in young individuals (before their reproductive maturity) may then be consequence of the premature derangement of such fundamental developmental constraints. In all cases the result is the loss of morphological coherence within the organism. Thus representing a conflict between an organized morphology (the organism) and a part of such a morphology that drifts towards an amorphous state (the tumor). (shrink)

The unit of selection is the concept of that ‘something’ to which biologists refer when they speak of an adaptation as being ‘for the good of’ something. Darwin identified the organism as the unit of selection because for him the ‘struggle for existence’ was an issue among individuals. Later on it was suggested that, in order to understand the evolution of social behavior, it is necessary to argue that groups, and not individuals, are the units of selection. The last addition (...) to this debate was the formulation by Dawkins, in 1976, that the genes themselves are the units of selection while the organisms are merely the temporary receptacles and vehicles for such genes. Thus, the preposterous dissolution of the organism into genes and the proteins coded by such genes has been introduced in the evolutionary discourse by neglecting that the explanations for biological phenomena can be either synchronic or diachronic, depending on the phenomenon to be explained. Therefore explanations in molecular biology are synchronic while evolutionary biology needs diachronic explanations. Nevertheless, for ultra-Darwinians such as Dawkins, efficient replication is all that biology is about. Here I develop an argument in order to show that there is nothing in molecular and cell biology that might support such a contention and that the idea of the gene as the unit of selection is incompatible with the evident evolution of biological complexity. (shrink)

The unit of selection is the concept of that ‘something’ to which biologists refer when they speak of an adaptation as being ‘for the good of’ something. Darwin identified the organism as the unit of selection because for him the ‘struggle for existence’ was an issue among individuals. Later on it was suggested that, in order to understand the evolution of social behavior, it is necessary to argue that groups, and not individuals, are the units of selection. The last addition (...) to this debate was the formulation by Dawkins, in 1976, that the genes themselves are the units of selection while organisms are merely the temporary receptacles and vehicles for such genes. Thus, the preposterous dissolution of the organism into genes and the proteins coded by such genes has been introduced in the evolutionary discourse by neglecting that the explanations for biological phenomena can be either synchronic or diachronic, depending on the phenomenon to be explained. Therefore explanations in molecular biology are synchronic while evolutionary biology needs diachronic explanations. Nevertheless, for ultra-Darwinians such as Dawkins, efficient replication is all that biology is about. Here I develop an argument in order to show that there is nothing in molecular and cell biology that might support such a contention and that the idea of the gene as the unit of selection is incompatible with the evident evolution of biological complexity. (shrink)

The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a (...) framework for the formal representation of protein classes and protein forms in the OBO Foundry. It is designed to enable data retrieval and integration and machine reasoning at the molecular level of proteins, thereby facilitating cross-species comparisons, pathway analysis, disease modeling and the generation of new hypotheses. (shrink)

Abstract: This study focused on comparative assessment of the implementation of quality assurance mechanisms in educational management programme of federal and state universities in south-east, Nigeria. Four research questions and four null hypotheses guided the study. The study was carried out in the eight government-owned (3 federal and 5 state) universities in south-east that run educational management programme. The study adopted a survey research design on a population of eight heads of department. A 44-item researcher constructed questionnaire was used to (...) rate the implementation of quality assurance mechanisms as it relates to; moderation of examination, in-service professional development programmes, mock accreditation exercise, and infrastructural facilities. The instrument was validated by three experts, while a grand reliability index of 0.84 was obtained using crombach alpha reliability coefficient. Mean scores were used to answer the four research questions while t-test was used to test the four null hypotheses at 0.05 level of significance. The major findings of the study indicated that both federal and state universities in south-east implement the four mechanisms for quality assurance in educational management programme to a little extent. Though they both have implemented it to a little extent, the federal universities seem to record better implementation of these mechanisms compared to the state universities. This is supported by the outcome of research questions 3 & 4 as well as hypotheses 3 & 4. It was recommended among others that the National Universities Commission (NUC) should lay more emphasis on the state universities during the usual general/main accreditation exercise of institutions. This will reduce the differences that may exist in standard. Conclusions, implications and limitations of the study were made as well as suggestions for further studies. (shrink)

Salah satu persoalan yang muncul dalam pendidikan di Indonesia adalah masalah kurikulum yang merupakan kebijakan pemerintah. Kurikulum yang diberlakukan di Indonesia, khususnya pada masa Orde Baru, dipandang oleh sebagian orang memiliki kepentingan politik dan terlalu sentralistik (terpusat). Melihat keadaan dan situasi pendidikan Indonesia yang demikian, ada harapan yang ditumbuhkan dengan munculnya tokoh Y.B. Mangunwijaya yang memiliki perhatian terhadap pendidikan khususnya pada anak miskin. Menurut Mangunwijaya, pola pendidikan Barat yang dibawa oleh para penjajah Belanda telah menggeser pola pendidikan tradisional Jawa yang (...) hanya menempatkan anak dalam posisi sekunder menjadi menghargai anak sebagai individu yang merdeka. Tetapi kemudian pada era Orde Baru, pemerintahan kembali mematikan kebebasan dan kreativitas anak dengan sistem pendidikan yang hanya menyuburkan kepawangan dan mental inggih ndoro pada guru dan anak-anak. Y.B. Mangunwijaya memiliki banyak konsep tentang pendidikan. Beberapa di antaranya adalah Pendidikan dan Kebudayaan Rakyat Semesta (P dan K Rata), Masyarakat Belajar (MB), Belajar Seumur Hidup (BUH), dan Kita Saling Belajar dan Mengajar, yang kesemuanya bersinggungan dengan filsafat pedagogi kritis. Kontribusi filsafat pendidikan Y.B. Mangunwijaya adalah pembangunan Sekolah Dasar Eksperimental Kanisius Mangunan yang dijalankan menggunakan konsep pemikirannya terhadap pendidikan, dibantu oleh Dinamika Edukasi Dasar (DED) sebagai bentuk pembaharuan pendidikan. (shrink)

Sentencing outcomes turn on moral and evaluative determinations. For example, a finding of “irreparable corruption” is generally a precondition for juvenile life without parole. A finding that the “aggravating factors outweigh the mitigating factors” determines whether a defendant receives the death penalty. Should such moral determinations that expose defendants to extraordinary penalties be subject to a standard of proof? A broad range of federal and state courts have purported to decide this issue “in the abstract and without reference to our (...) sentencing case law,” as the Supreme Court recently put it. Kansas v. Carr, 577 U.S. 108, 119 (2016). According to these courts, “it would mean nothing” to ask whether the defendant “deserves mercy beyond a reasonable doubt” or “more-likely-than-not deserves it” because moral questions are not “factual.” Instead, moral determinations are highly subjective “value calls” to which concepts of doubt and certainty do not intelligibly apply. -/- Implicit in these rulings is a controversial view of the nature of moral judgment. This Article traces the contours of the view and argues that it is out of step with the way the broader public thinks about morality and fails to address the issues defendants have raised. Courts should avoid wading into such controversial waters for two reasons. First, the judiciary has historically maintained neutrality on issues of significant public concern. Second, even if moral determinations are not factual, applying a standard of proof to at least some moral decisions at sentencing would change the outcome of the sentencer’s deliberations, and improve the legitimacy of the legal system. For the reasonableness of doubt depends on context; and moral questions—"are you certain the defendant deserves death?”—make salient the stakes relative to which a person should decide what to believe about ordinary empirical matters. On the resulting view, reasonable doubt in the final moral analysis is not just intelligible, but essential for correcting a bias in the structure of the bifurcated criminal trial that systematically disadvantages defendants: the tendency for de-contextualized "factual findings” in the guilt phase to control outcomes at sentencing. (shrink)

This essay is a response to Luis M. Augusto’s intriguing paper on the rift between mainstream and formal ontology. I will show that there are in fact two questions at issue here: 1. concerning the links between mainstream and formal approaches within philosophy, and 2. concerning the application of philosophy (and especially philosophical ontology) in support of information-driven research for example in the life sciences.

Kierkegaard faces an apparent dilemma. On the one hand, he concurs with the biblical injunction: we are to love our neighbors as ourselves. He takes this to imply that self-love and neighbor-love should be roughly symmetrical, similar in kind as well as degree. On the other hand, he recommends relating to others and to ourselves in disparate ways. We should be lenient, charitable, and forgiving when interacting with neighbors; the opposite when dealing with ourselves. The goal of my paper is (...) to solve this puzzle. I first consider addressing it by appealing to Gene Outka’s idea that equal love does not entail identical treatment. After rejecting this solution, I offer my own: Asymmetry between the two loves is not a moral ideal for Kierkegaard but a rehabilitative strategy. He recommends being more latitudinarian with others than with ourselves to correct against a common tendency toward the opposite extreme. (shrink)

Teleology has a complicated history in the biological sciences. Some have argued that Darwin’s theory has allowed biology to purge itself of teleological explanations. Others have been content to retain teleology and to treat it as metaphorical, or have sought to replace it with less problematic notions like teleonomy. And still others have tried to naturalize it in a way that distances it from the vitalism of the nineteenth century, focusing on the role that function plays in teleological explanation. No (...) consensus has seemed possible in this debate. This paper takes a different approach. It argues that teleology is a perfectly acceptable scientific notion, but that the debate took an unfortunate misstep some 2300 years ago, one that has confused things ever since. The misstep comes in the beginning of Aristotle’s Physics when a distinction is made between two types of teleological explanation. One type pertains to artifacts while the other pertains to entities in nature. For Aristotle, artifacts are guided by something external to themselves, human intentions, while natural entities are guided by an internal nature. We aim to show that there is, in fact, only one type of legitimate teleological explanation, what Aristotle would have considered a variant of an artifact model, where entities are guided by external fields. We begin with an analysis of the differences between the two types of explanation. We then examine some evidence in Aristotle’s biological works suggesting that on account of his natural-artifactual distinction, he encountered difficulties in trying to provide teleological accounts of spontaneous generation. And we show that it is possible to resolve these difficulties with a more robust version of an artifact model of teleology, in other words, with an externalist teleology. This is McShea’s model, in which goal-directed entities are guided by a nested series of upper-level fields. To explain teleological behavior, this account invokes only external physical forces rather than mysterious internal natures. We then consider how field theory differs from other efforts to naturalize teleology in biology. And finally, we show how the account enables us to grapple with certain difficult cases – genes and intentions – where, even in biology today, the temptation to posit internal natures remains strong. (shrink)

This paper poses a problem for traditional phylogenetics: The identity of organisms that reproduce through fission can be understood in several different ways. This prompts questions about how to differentiate parent organisms from their offspring, making vertical gene transfer unclear. Differentiating between parents and offspring stems from what I call the identity problem. How the problem is resolved has implications for phylogenetic groupings. If the identity of a particular asexual organism persists through fission, the vertical lineage on a phylogenetic (...) tree will split differently than if the identity of an organism does not survive the fission process. (shrink)

This essay is dedicated to elaborating some of the stylistic elements at work in Nietzsche's polemical book, On The Genealogy of Morals with particular attention to the nature of the aphorism from its inception in ancient Greek literaure, Nietzsche's specific deployment of the aphorism as such, including Nietzsche's argument structure and rhetorical technique as well as the language of Greek and Jewish antiquity, master and slave. -/- In: Christa Davis Acampora, ed., Nietzsche’s On the Genealogy of Morals: Critical Essays (Lanham, (...) Md., Rowman & Littlefield, 2006), pp. 177-190. (shrink)

The contrast between Kant’s moral philosophy and Feder’s is not less crucial than the controversy caused by the Göttingen review of the first Critique. One of main targets of Kant’s moral philosophy was Feder’s view, which can be regarded as Kant's main competitor in the contemporary debate. I thus argue that the background provided by the conflict with Feder shows significant distinctive traits of Kant's view, with regard to three fundamental issues. First, I examine how the project (...) of a pure moral philosophy opposes Feder’s empirical investigation into the will, which is in fact one of the targets of Kant's criticism against universal practical philosophy. Second, a central element of Kant’s anti-eudaemonism, the contrast between happiness and self-contentment, is a rejection of the strongly moralized view of happiness that underlies Feder’s eudaemonism. Finally, I examine Tittel's objection that Kant had provided "only a new formula" of morality and Kant's response, which display a fundamental contrast between Kant’s understanding of the aims of moral theory with Feder’s common-sense conception. (shrink)

A far-reaching and influential view in evolutionary biology claims that species are cohesive units held together by gene flow. Biologists have recognized empirical problems facing this view; after sharpening the expression of the view, we present novel conceptual problems for it. At the heart of these problems is a distinction between two importantly different concepts of cohesion, what we call integrative and response cohesion. Acknowledging the distinction problematizes both the explanandum of species cohesion and the explanans of gene (...) flow that are central to the view we discuss. We conclude by tracing four broader implications for the study and conceptualization of species. (shrink)

What is a race? Ernst Mayr (1904–2005) distinguishes between species in which biological change is continuous in space, and species in which groups of populations with different character combinations are separated by borders. In the latter species, the entities separated by borders are geographic races or subspecies. Many anthropology textbooks describe human races as discrete (or nearly discrete) clusters of individuals, geographically localized, each of which shares a set of ancestors, and hence can be distinguished from other races by their (...) common gene pool or by different alleles fixed in each. (shrink)